Abstract #2292

Urinary bladder as an in vivo reference for quality assurance of apparent diffusion coefficient for prostate MRI

Liam S. P. Lawrence¹, Rachel W. Chan², Mohamed Al Sharji³, Rajesh Bhayana⁴, Angus Z. Lau^1,5, and Masoom A. Haider^4,6

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Medical Imaging, University of Toronto, Toronto, ON, Canada, ⁴Joint Department of Medical Imaging, Sinai Health System, Toronto, ON, Canada, ⁵Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Synopsis

Keywords: Cancer, Precision & Accuracy, ADC, quality assurance, prostate cancer

Motivation: Diagnostic accuracy for prostate cancer could be improved by quantitative assessment of apparent diffusion coefficient (ADC), but quality assurance would require an in vivo reference for each exam.

Goal(s): Determine whether urinary bladder ADC is unbiased relative to normal saline across ADC fitting methods.

Approach: In 103 prostate cancer patients, urinary bladder ADC was compared to ADC of normal saline in the balloon of an endorectal catheter. ADC fitting methods were compared across prostate regions.

Results: Using weighted linear least-squares fitting and an intermediate range of b-values (100≤b≤600s/mm²), urinary bladder ADC is unbiased and fitting error is minimized.

Impact: The urinary bladder serves as a reference sample for ADC, which will be necessary for quality assurance of ADC in prostate cancer diagnosis. Whether prostate ADC normalization by bladder ADC reduces interpatient variability can be investigated.

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