Keywords: CEST / APT / NOE, CEST / APT / NOE, Histogram Analysis, Brain Abscesses, Cystic High-grade Gliomas
Motivation: Improve non-invasive methods for distinguishing brain abscesses from cystic high-grade gliomas, addressing the need for accurate differential diagnosis in clinical practice.
Goal(s): Evaluate the effectiveness of 3D Amide Proton Transfer-weighted imaging (APTw) MRI histogram analysis as a diagnostic tool for distinguishing these lesions.
Approach: A retrospective study was conducted, analyzing APTw histogram data from two groups. Histogram parameters were extracted from two distinct ROIs and compared between two groups.
Results: APTw histogram metrics across different ROIs provided diagnostic performance from moderate to excellent, suggesting APTw-based histogram analysis as a valuable, non-invasive approach for differentiating two diseases, with potential for integration into diagnostic protocols.
Impact: This study is the first to utilize APTw imaging to differentiate between brain abscesses and cystic high-grade gliomas. The results highlight the potential of APTw as a valuable imaging biomarker, supporting its utility in improving diagnostic accuracy.
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