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Abstract #2305

Histogram Analysis of 3D Amide Proton Transfer-weighted MRI for Distinguishing Brain Abscesses from Cystic High-grade Gliomas

Xia Zou1,2, Yongzhou Xu3, and Zhibo Wen1
1Department of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China, 2The First Affiliated Hospital of Nanchang University, Nanchang, China, 3Philips Healthcare, Guangzhou, China

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE, Histogram Analysis, Brain Abscesses, Cystic High-grade Gliomas

Motivation: Improve non-invasive methods for distinguishing brain abscesses from cystic high-grade gliomas, addressing the need for accurate differential diagnosis in clinical practice.

Goal(s): Evaluate the effectiveness of 3D Amide Proton Transfer-weighted imaging (APTw) MRI histogram analysis as a diagnostic tool for distinguishing these lesions.

Approach: A retrospective study was conducted, analyzing APTw histogram data from two groups. Histogram parameters were extracted from two distinct ROIs and compared between two groups.

Results: APTw histogram metrics across different ROIs provided diagnostic performance from moderate to excellent, suggesting APTw-based histogram analysis as a valuable, non-invasive approach for differentiating two diseases, with potential for integration into diagnostic protocols.

Impact: This study is the first to utilize APTw imaging to differentiate between brain abscesses and cystic high-grade gliomas. The results highlight the potential of APTw as a valuable imaging biomarker, supporting its utility in improving diagnostic accuracy.

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