Keywords: CEST / APT / NOE, CEST & MT, fluid suppression, brain tumor, APTw-MRI, visualization, MT correction, spillover, noise
Motivation: APTw-MRI evolves for brain tumor diagnosis and treatment monitoring, while metrics/visualization are still debated. MTR-asymmetry under/overestimates chemical exchange at high/low MT, but MT-correction enhances background-noise. Fluid-suppression simplifies diagnosis in necrosis (cysts). While partly addressed, a combined method is needed.
Goal(s): Define an MT-correction with extra fluid suppression and noise reduction. Evaluate in glioblastoma patients.
Approach: MT-correction with MTRrex for solid tumors, rescaled for extra fluid suppression (necrosis) and a noise limit (NAWM), is compared to previous proposals on 12 glioblastoma patients with 2D FSE, 2μT/2s saturation on 3.0T-MRI.
Results: MT-correction in solid tumors is shown with high CNR and efficient suppression of necrosis.
Impact: The rescaled metric may provide a standard for displaying APTw contrast in tumor diagnosis and response assessment, combining MT-corrected and low noise quantitative assessment of chemical exchange in solid tumor areas with extra fluid suppression for efficient clinical reading.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords