Abstract #2307

R1rho Dispersion Imaging to Detect Proteoglycan Loss in the Intervertebral Discs in Swine Models

Mitchell J Christiansen^1,2, Sylvia E Perez², Mark C Preul³, Jay D Turner⁴, Juan S Uribe⁴, Elliott J Mufson², Daniel Yang⁵, Wonsuk Yoo⁶, John C Gore⁷, Richard D Dortch², and Ping Wang²

¹Creighton University School of Medicine, Phoenix, AZ, United States, ²Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, ³Neurosurgery Research Laboratory, Barrow Neurological Institute, Phoenix, AZ, United States, ⁴Barrow Neurological Institute, Phoenix, AZ, United States, ⁵Basis Mesa, Mesa, AZ, United States, ⁶Transaltional Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, ⁷Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States

Synopsis

Keywords: CEST / APT / NOE, biomarkers, R1rho dispersion imaging

Motivation: R1rho imaging can provide novel information on dynamic processes within tissues, allowing for a more comprehensive analysis of the parameters of chemical exchange.

Goal(s): To examine the feasibility of using R1rho dispersion imaging to detect proteoglycan loss in spine disc degeneration.

Approach: R1rho imaging was performed in the intervertebral discs of swine spine specimens before and after the treatment to induce proteoglycan loss. Student’s t-test was employed to examine the statistical significance of the R1rho dispersion before and after the treatment.

Results: The Student’s t-test showed significant difference between the R1rho dispersion measured before and after the treatment on the disc specimens.

Impact: The study suggested that R1rho dispersion can detect the proteoglycan loss in spine discs, potentially making it a promising tool for the early detection of disc degeneration.

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