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Abstract #2335

Crossing the scales: Opto-magnetic imaging can reveal cortical propagation of circuit-dominating slow wave events

Dirk Ernst Cleppien1, Miriam Schwalm2, Hendrik Backhaus1, Ting Fu1, Felipe Aedo-Jury1, Gaby Schneider3, and Albrecht Stroh1,4
1Leibniz Institute for Resilience Research, Mainz, Germany, 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States, 3Institute of Mathematics, Department of Computer Science and Mathematics, Goethe University Frankfurt, Frankfurt, Germany, 4Institute of Physiology I, Neurophysiology, University Hospital Muenster (UKM), Muenster, Germany

Synopsis

Keywords: Mesoscale: columns and layers, Neuroscience, Slow waves

Motivation: Slow wave events (SWEs) or population up states occur in the mammalian cortex mainly during sleep or under anesthesia. Disrupted SWE propagation activity may be implicated in early-stage neurological disorders

Goal(s): Following the slow wave event (SWE) as a distinct neurophysiological event across the scales in rodents.

Approach: We explore the neuronal recruitment and propagation of SWE from single neurons to the cortex, intertwining optical and translationally relevant fMRI.

Results: All active cells of the local microcircuit participate in a population wide SWE. Implementing an optomagnetic integration concept (OPTOMAIC), we could measure cortical propagation velocities of neurophysiologically-defined SWEs by non-invasive fast fMRI.

Impact: This study bridges concepts and methods spanning from optical imaging of local microcircuits to optic-fiber photometry and fast fMRI to follow a defined neurophysiological event, the slow wave event, across the scales, from single cells to non-invasive cortex wide fMRI.

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