Abstract #2362

Anatomical location related hemodynamic variations are associated with MCA atherosclerosis: a preliminary 4D flow and 3D vessel wall MRI study

Peirong Jiang¹, Lixin Liu², Huiyu Qiao³, Xiuzhu Xu¹, Yanping Zheng¹, Lin Lin¹, Jialin Chen⁴, Bin Sun¹, He Wang^2,5, Xihai Zhao⁶, Zhensen Chen^2,5, and Yunjing Xue¹

¹Radiology, Fujian Medical University Union Hospital, Fuzhou, China, ²Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ³School of Biomedical Engineering, Capital Medical University, Beijing, China, ⁴Neurology, Fujian Medical University Union Hospital, Fuzhou, China, ⁵Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China, ⁶Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

Synopsis

Keywords: Stroke, Flow, atherosclerosis, wall shear stress, middle cerebral artery

Motivation: The relationships between flow alterations due to plaque existence and number in different intracranial arterial segments have not been fully understood.

Goal(s): This study aims to investigate WSS and OSI alterations between nonplaque and atherosclerotic MCA segments and explore the potential hemodynamic discrepancy between multiple- and single-plaque existence.

Approach: TAWSS and OSI were measured at five cross-sectional slices (initial, upstream, minimal lumen area, downstream, and terminal) of plaque as well as segments.

Results: TAWSS and OSI distributed variedly between nonplaque and atherosclerotic MCA segments, and between single- and multiple-plaque presence.

Impact: Arterial segment, plaque number and plaque characteristics may have a significant interplay with the local hemodynamic environment, which could provide insight for atherosclerotic development.

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