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Abstract #2363

Assessing the Predictive Impact of Corticocerebellar Pathway Integrity on Stroke Motor Outcomes

Jing Liu1, yi Shan1, Bi-xiao Cui1, Shao-zhen Yan1, Lin-lin Ye2, Bo-yan Xu3, Lei Cao2, Miao Zhang1, and Jie Lu1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, 2Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China, 3GE Healthcare, MR Research China, Beijing, Beijing, China

Synopsis

Keywords: Stroke, DWI/DTI/DKI, anisotropy fraction ◼ diffusion tensor imaging ◼ middle cerebral artery ◼ stroke ◼ corticocerebellar pathway ◼motor recovery

Motivation: Motor impairment is a major consequence of middle cerebral artery infarction. Evaluating cerebellar pathways could enhance motor rehabilitation.

Goal(s): To assess corticocerebellar pathway (CCP) integrity and its role in predicting motor recovery.

Approach: Twenty-nine MCA infarction patients and 29 controls underwent DTI scanning. Fractional anisotropy (FA) values and FA asymmetry indices (FA-AI) of CCP tracts were evaluated.

Results: Patients showed significantly lower FA values and FA-AI in the dentate-thalamocortical tract (DTCT) and dorsal spinocerebellar tract (DSCT). FA-AI of DTCT predicted upper-limb recovery, while FA-AI of DSCT predicted lower-limb outcomes, indicating their distinct contributions to motor rehabilitation.

Impact: Our study highlights the importance of corticocerebellar pathway integrity in predicting motor recovery after stroke. These insights can enhance early prognosis and guide personalized rehabilitation strategies for patients with middle cerebral artery infarction.

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Keywords