Abstract #2365

A Longitudinal Study of T2 Mapping and DTI to Quantitatively Evaluate Neuroprotective Effect of rTMS on Ischemic Rat Brain

Qiya Zhang¹, Azzam Saeed², Xiangyu Tang², Haoyue Shao², Weiyin Vivian Liu³, Shuting Huang², Chaoxu Liu⁴, Feng Guo⁵, Li Peng², and Wenzhen Zhu⁶

¹Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, wuhan, China, ²Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³MR Research, GE Healthcare, Beijing, China, ⁴Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ⁵Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ⁶Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Synopsis

Keywords: Stroke, Stroke, rTMS; T2 mapping; DTI

Motivation: Repetitive transcranial magnetic stimulation (rTMS) is a promising non-invasive neuromodulation technique that can promote neuroplasticity. However, the underlying therapeutic mechanisms remain insufficiently elucidated.

Goal(s): Using T2 mapping and diffusion tensor imaging (DTI) to observe the structural and pathophysiological changes in the brain following rTMS treatment for ischemic stroke.

Approach: We applied T2 mapping and DTI at multiple time points after acute ischemic stroke to observe the effect of rTMS.

Results: 2-week rTMS treatment significantly reduced rT2 value, increased rFA value and reduced the values of rAD, rRD and rMD in cortex and basal ganglia compared to the control group, with improved neurological function.

Impact: Parameters derived from T2 mapping and DTI can be used together as imaging biomarkers to assess the neuroprotective effect of rTMS on ischemic stroke. The longitudinal quantitative MRI evaluation provided new insights into the rTMS treatment for acute ischemic stroke.

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