Keywords: Stroke, PET/MR, carotid stenosis, PET/MR, white matter hyperintensities, vulnerable plaque, brain metabolism
Motivation: The specific features of carotid plaques that contribute to the progression of white matter hyperintensities (WMH) in patients with carotid artery stenosis remain unclear.
Goal(s): To identify which carotid plaque characteristics can predict the worsening of WMH grades over a one-year period.
Approach: We conducted a prospective study with 134 patients undergoing baseline and one-year follow-up PET/MR imaging. We evaluated carotid plaque and vessel wall indexes , WMH volumes and grades were quantified, and multivariate regression analyses determined associations between plaque indicators and WMH progression.
Results: High baseline PET uptake and the presence of AHA type VI plaques were independently associated with WMH progression.
Impact: By identifying carotid plaque features that predict WMH progression, this study enables early identification of high-risk patients, guiding targeted interventions to prevent cerebral vessel disease progression and cognitive decline in those with carotid artery stenosis.
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