Abstract #2369

Molecular basis of Gray Matter Volume Alterations in Ipsilesional and Contralesional Hemispheres after Subcortical Stroke

Tao Jin¹, Huaijin Gao¹, Wenjun Hong², Rong Xu², Zaixing Liu², Yanan Wu², Dan Wu^1,3, Yihan Ma¹, and Zhiyong Zhao^1,3

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Rehabilitation Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, NanJing210008, China, ³Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China

Synopsis

Keywords: Stroke, Genetics, cell type, gray matter volume

Motivation: The molecular basis underlying differences between the ipsilesional and contralesional hemispheres in structural alterations after stroke remains unclear.

Goal(s): We aimed to investigate the molecular basis of differences between the ipsilesional and contralesional hemispheres in structure after stroke.

Approach: Gray matter volume (GMV) data from stroke patients were integrated with transcriptional data from the Allen Human Brain Atlas. Correlations between GMV changes and gene expression were analyzed, followed by gene enrichment and cell-type-specific analyses.

Results: Ipsilesional GMV decreases were linked to cellular stress and immune responses, while contralesional GMV increases were associated with synaptic and axon development, with specific ties to excitatory cells.

Impact: Our findings demonstrate that contralesional increase and ipsilesional decrease in the GMV after stroke were linked to different molecular pathways and cellular types. These findings provide new insights into understanding brain damage and compensatory mechanisms after stroke.

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