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Abstract #2373

Application of Combined APT and NODDI Imaging Techniques for Diagnosing IDH Mutations in Diffuse Glioma

Chuyun Tang1, Ling Chen1, Yifan Xu1, Wei Cui2, and Zisan Zeng1
1Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guang, Nanning, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Tumors (Pre-Treatment), Diagnosis/Prediction, NODDI

Motivation: Isocitrate dehydrogenase (IDH) mutation status is crucial for diffuse glioma prognosis and treatment, yet non-invasive prediction methods remain underdeveloped.

Goal(s): To assess the diagnostic efficacy of APT and NODDI imaging, along with their combination, for predicting IDH mutation status in diffuse gliomas.

Approach: Fifty diffuse glioma patients (25 IDH wild-type and 25 IDH-mutant) were recruited. APT and NODDI parameters in tumor parenchyma were compared between groups, and logistic regression was used to combine optimal parameters to build a predictive model.

Results: The combined APT and ICVF approach achieved the highest diagnostic efficacy, with an AUC of 0.794.

Impact: The combined APT and NODDI imaging approach offers an accurate, non-invasive method for predicting IDH mutations in diffuse gliomas, improving diagnosis and enabling personalized treatment.

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