Keywords: Tumors (Pre-Treatment), Cancer
Motivation: Field Cycling Imaging (FCI) is a new imaging modality that shows high potential in brain glioma from ex-vivo studies.
Goal(s): Our goal was to demonstrate the capabilities of FCI as an imaging modality to detect brain cancer in vivo.
Approach: Nine patients were imaged with our recent FCI prototype scanner using fields from 0.2 to 200mT. T1 images were compared with standard 1.5T MRI clinical images.
Results: Tissue contrast appeared between tumours and uninvolved tissues that agreed with ex-vivo results, showing biomarkers of aquaporins activity. This discriminated gliomas from peritumoural regions, as well as gliomas from meningiomas.
Impact: FCI can detect brain tumour and discriminates glioma from meningioma. Tissue dispersion may also be a marker of aggressiveness. These offer interesting prospects for clinical applications.
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