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Abstract #2383

The Value of synthetic MRI Combined with Amide Proton Transfer Imaging in Predicting IDH1 Gene Status in Gliomas

Meng Sun1, Xiaodong Wang1, Guangxu Han2, Yuhui Xiong2, Xin Ge3, Wenfu Ma1, Yixuan Jin1, Fang Niu1, and Jiaxin Zhou1
1General Hospital of Ningxia Medical University, Ningxia, China, 2GE HealthCare MR Research, Beijing, China, 3The Second Clinical Medical College of Lanzhou University, Lanzhou, China

Synopsis

Keywords: Tumors (Pre-Treatment), Quantitative Imaging, Tumors (Pre-Treatment), IDH1,APT,synthetic MRI,Glioma

Motivation: Mutations in the IDH1 gene are pivotal in the pathogenesis,classification, and prognostic evaluation of gliomas. Predicting these mutations using non-invasive methods is of substantial clinical importance.

Goal(s): To explore the capability of synthetic MRI combined with Amide Proton Transfer (APT) in predicting the IDH1 gene status in gliomas.

Approach: 51 IDH1-mutant and 34 IDH1-wildtype glioma patients were collected to compare their synthetic MRI and APT quantitative parameters, the diagnostic value of these parameters in predicting IDH1 gene status being assessed.

Results: The quantitative parameters of synthetic MRI and APT are effective in predicting IDH1 mutation status.Their combined application achieves the highest predictive performance.

Impact: The combination of synthetic MRI and APT provides a novel and reliable non-invasive diagnostic method for predicting IDH1 gene status, offering an valuable imaging approach for the development of personalized treatment plans and prognostic assessments in clinical practice.

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Keywords