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Abstract #2384

R1-R2* relaxivity captures altered iron homeostasis in normal appearing contratumoral brain regions of glioblastoma patients

Alberto Galimberti1, Stephanie Mangesius1, Julian Mangesius1, Johannes Kerschbaumer1, Christian Freyschlag1, Ute Ganswindt1, Elke Gizewski1, and Christoph Birkl1
1Medical University Innsbruck, Innsbruck, Austria

Synopsis

Keywords: Tumors (Pre-Treatment), Quantitative Imaging

Motivation: Our aim is to obtain a robust quantitative MRI measure of iron homeostasis which can further help predict glioblastoma patients’ treatment outcome.

Goal(s): Can MR relaxometry-derived measures associated with iron homeostasis be linked to neuropathological factors and patients’ survival?

Approach: Using an innovative quantitative MRI technique (R1-R2* relaxivity), we examined iron homeostasis across contratumoral brain regions in glioblastoma patients, aiming to link these patterns with patient outcomes and neuropathological factors. Moreover, we compared the predictive power of the R1-R2* relaxivity measure with that of R1 and R2*.

Results: R1-R2* relaxivity in multiple brain regions showed associations with patients’ specific characteristics.

Impact: This study explores iron homeostasis in the “non-affected” hemisphere in glioblastoma patients. R1-R2* relaxivity model could serve as a valuable non-invasive biomarker for iron homeostasis, potentially allowing early detection of recurrence and guiding clinical decision making and treatment planning.

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