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Abstract #2388

Dynamic Brain Entropy of Peritumoral Region in Patients with Glioma Associated Epillepsy

Siqi Cai1, Zhen Fan2, Zengxin Qi2, Zhifeng Shi2, and Lijuan Zhang1,3
1Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Neurosurgery, Huashan Hospital of Fudan University, Shanghai, China, 3University of Chinese Academy of Sciences, Beijing, China

Synopsis

Keywords: Tumors (Pre-Treatment), Epilepsy, cerebral glioma, brain entropy, dynamic

Motivation: The effect of the peritumoral tissue on the occurrence of glioma-associated epilepsy (GAE) remains to be fully elucidated.

Goal(s): To develop a scheme of fMRI-based dynamic brain entropy to investigate the dynamic fluctuations of brain activity within tumor and peritumoral regions as a result of GAE.

Approach: Individualized functional mapping method was utilized to identify the preserved functional region surrounding tumors. Sliding-window approach and wavelet entropy (WaveEp) analysis were utilized to quantify the temporal irregularity of BOLD signals.

Results: Patients with GAE showed higher standard deviation of dynamic WaveEp within the preserved peritumoral functional regions as compared to those without epilepsy.

Impact: The fMRI-based dynamic wavelet entropy analysis provides a macroscopic metric to characterize the aberrant dynamic fluctuations in resting brain activity of peritumoral regions in patients with glioma-associated epilepsy.

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