Keywords: Tumors (Pre-Treatment), Epilepsy, cerebral glioma, brain entropy, dynamic
Motivation: The effect of the peritumoral tissue on the occurrence of glioma-associated epilepsy (GAE) remains to be fully elucidated.
Goal(s): To develop a scheme of fMRI-based dynamic brain entropy to investigate the dynamic fluctuations of brain activity within tumor and peritumoral regions as a result of GAE.
Approach: Individualized functional mapping method was utilized to identify the preserved functional region surrounding tumors. Sliding-window approach and wavelet entropy (WaveEp) analysis were utilized to quantify the temporal irregularity of BOLD signals.
Results: Patients with GAE showed higher standard deviation of dynamic WaveEp within the preserved peritumoral functional regions as compared to those without epilepsy.
Impact: The fMRI-based dynamic wavelet entropy analysis provides a macroscopic metric to characterize the aberrant dynamic fluctuations in resting brain activity of peritumoral regions in patients with glioma-associated epilepsy.
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