Abstract #2391

A novel approach to the metabolic characterisation of brain tumours: edema-corrected OEF. A hybrid MR-PET study.

Ana-Maria Oros-Peusquens*¹, Junghun Cho², Frank Boers¹, Ilnaz Fazli Jaliseh¹, Karl-Josef Langen¹, and N. Jon Shah^1,3,4,5,6

¹Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, ²Biomedical engineering, State university of new York at buffalo, Buffalo, NY, United States, ³JARA - BRAIN - Translational Medicine, Aachen, Germany, ⁴Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Jülich, Germany, ⁵JARA - BRAIN - Translational Medicine, Forschungszentrum Jülich, Aachen, Germany, ⁶Department of Neurology, RWTH Aachen University, Aachen, Germany

Synopsis

Keywords: Tumors (Pre-Treatment), Tumors, Oxygenation, Hybrid MR-PET, Water content, Relaxometry, Multicomponent analysis

Motivation: Characterize hypoxia and water content in metabolically active brain tumour tissue and edema.

Goal(s): Investigate tumour oxygenation without the confounding effect of edema, defined as increased free water content. Compare corrected values to ¹⁸F-FET PET as a marker of tumour malignancy.

Approach: A single mGRE acquisition measures water content, T₂*, OEF, venous blood volume and venous blood-corrected parameters χ_tissue and R₂*_tissue. Multicomponent relaxometry separates free and tissue water enabling edema correction

Results: OEF and PET values are uncorrelated before and after edema correction and can be used to characterise different aspects of tumour respiration and malignancy

Impact: A simple and fast acquisition method enables quantitative and metabolic characterisation of brain tumours and can be implemented in large and multicentre patient studies. Applying edema correction makes the properties of underlying tissue accessible, potentially enabling more precise tumour characterisation.

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