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Abstract #2393

Fluid suppressed amide proton transfer weighted imaging for distinguishing true progression from treatment response in post-treatment gliomas

Chun-Qiu Su1, Jing-Wen Hou1, Xian-Ce Zhao2, and Shan-Shan Lu1
1The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2Philips Healthcare, Shanghai, China

Synopsis

Keywords: Tumors (Post-Treatment), Neuro

Motivation: Distinguishing tumor progression from treatment response, following brain tumor therapy remains a major clinical challenge.

Goal(s): To assess the diagnostic performance of fluid suppressed amide proton transfer-weighted (FS-APTW) imaging in distinguishing true progression from treatment response with post-treatment gliomas.

Approach: We conducted APTW and FS-APTW imaging on 66 patients with post-treatment gliomas. The APTWmean and FS-APTWmean signals were obtained from enhanced lesions and peritumoral edema for each patient and compared between the true progression and treatment response groups.

Results: The FS-APTW signal is a valuable imaging biomarker for distinguishing treatment response from true progression in post-treatment gliomas.

Impact: FS-APTW imaging offers a more specific characterization of true progression versus treatment response in post-treatment gliomas than APTW imaging.

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