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Abstract #2394

Initial experience of characterizing recurrent IDH-mutant astrocytoma using multi-parametric 1H/HP-13C MRI and histopathological analysis

Xiaonan April Xing1,2, Adam W. Autry1, Tracy L. Luks1, Marisa LaFontaine1, Devika Nair1, Janine M. Lupo1,2,3, Joanna J. Phillips4,5, Javier E. Villanueva-Meyer1,3, Hervey-Jumper Shawn4, Susan M. Chang4, and Yan Li1,2
1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Graduate Program in Bioengineering, UCSF/UC Berkeley, San Francisco & Berkeley, CA, United States, 3Center for Intelligent Imaging, UCSF, San Francisco, CA, United States, 4Department of Neurological Surgery, UCSF, San Francisco, CA, United States, 5Department of Pathology, UCSF, San Francisco, CA, United States

Synopsis

Keywords: Tumors (Post-Treatment), Hyperpolarized MR (Non-Gas), Brain tumor, Glioma, Astrocytoma, Hyperpolarized 13C, 1H imaging, biopsy

Motivation: Understanding the metabolic profile of glioma is crucial for enhancing diagnostic and treatment precision. This study leverages advanced imaging and histopathology to delve into glioma metabolism.

Goal(s): To integrate multi-parametric 1H/HP-13C MRI data with histopathological analysis of glioma biopsy samples, enabling detailed characterizations of metabolic dysregulation in glioma.

Approach: Four patients with IDH-mutant astrocytoma underwent multi-parametric 1H/HP-13C MR imaging before surgery, followed by histological analysis of tumor biopsy samples. Metabolic conversion rates and histological markers of hypoxia, vascularity, and proliferation were obtained.

Results: The findings reveal correlations between imaging-derived biomarkers and histopathological features, with correlations observed between Ki-67 expression and perfusion parameters.

Impact: This study advances the understanding of glioma metabolism through the integration of novel multi-parametric 1H/HP-13C MRI and tumor histopathological analysis. The insights can enhance precision in characterizing glioma, potentially guiding tailored treatment strategies.

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Keywords