Abstract #2400

Towards fully in-line single-voxel MRI spectroscopy for 2HG quantification as an IDH biomarker – can it eventually reach clinical use?

Angela Walls^1,2, Benjamin Crouch^1,3, Stephanie Withey⁴, Minh-Son To^3,5, Cherie Raven³, Santosh Poonnoose^5,6, Marc Agzarian^3,5, and Andrew M Dwyer^1,2,3,5

¹Clinical and Research Imaging Centre, South Australian Health and Medical Institute, Adelaide, Australia, ²Jones Radiology, Adelaide, Australia, ³South Australian Medical Imaging, Adelaide, Australia, ⁴Siemens Healthcare Pty Ltd, Adelaide, Australia, ⁵College of Medicine & Public Health, Flinders University, Adelaide, Australia, ⁶Department of Neurosurgery, Flinders Medical Centre, Adelaide, Australia

Synopsis

Keywords: Tumors (Pre-Treatment), Spectroscopy

Motivation: 2HG is a biomarker of IDH-mutation status in brain gliomas and could benefit the clinic but lack of accessible acquisition and analysis approaches hamper adoption.

Goal(s): Our goal was to remove barriers to 2GH-MRS in clinical workflow through use of available sequences, feasible scan time and in-line analysis methods.

Approach: Fully blinded analysis of clinically achievable MRI spectroscopy (PRESS 97ms) data using non-clinical and vendor software was compared with histopathologic IDH status.

Results: Approach was feasible and yielded similar accuracy to previously reported edited-MRS methods. Both analyses showed acceptable ROC but inline implementation was more challenging in borderline cases and some non-glial tumours.

Impact: 2HG-MRS achieved with routinely available acquisition in clinical workflow and translated to inline analysis software could promote 2HG as a usable biomarker for IDH status in practice.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.