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Abstract #2412

Comprehensive Multi-Modal MRI Templates of the Infant Brain: A Foundational Resource for Early Developing Brain Studies

Ruolin Li1,2, Runjia Lin1, Sovesh Mophapatra1,2, Fengxia Wu1,3, Wentao Wu1,2, Tianjia Zhu1,2, Cheng En Li1, Shufang Tan1,4, Kay L. Sindabizera1, Minhui Ouyang1,5, and Hao Huang1,5
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Anatomy and Neurobiology, Shandong University, Jinan, China, 4Department of Education, Peking University, Beijing, China, 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Normal Development, Multimodal, Infant Brain Atlas, Tractography, Early Development

Motivation: Infancy is characterized with fastest brain changes across the lifespan, with significant brain morphology differences in just several months. To precisely quantify these changes, dense age-specific infant templates and atlases are needed.

Goal(s): To create comprehensive age-specific templates for infant brains at 3, 6, 12, and 24 months, facilitating infant neuroimaging analyses.

Approach: We constructed age-specific infant templates using high-resolution structural and diffusion MRI data in the MNI-152 space.

Results: These templates capture anatomical differences across milestone infant ages, providing a foundational resource. We showcase two applications: mapping the short-range association fibers and charting the differential myelination trajectories in infant brains.

Impact: The established foundational resource for infant brain research offers dense and age-specific multi-modal MRI templates. This resource empowers researchers to conduct precise neuroimaging analyses of infants, unlocking insights into brain structure, function, and connectivity in both health and disease.

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