Keywords: Normal Development, Multimodal, Infant Brain Atlas, Tractography, Early Development
Motivation: Infancy is characterized with fastest brain changes across the lifespan, with significant brain morphology differences in just several months. To precisely quantify these changes, dense age-specific infant templates and atlases are needed.
Goal(s): To create comprehensive age-specific templates for infant brains at 3, 6, 12, and 24 months, facilitating infant neuroimaging analyses.
Approach: We constructed age-specific infant templates using high-resolution structural and diffusion MRI data in the MNI-152 space.
Results: These templates capture anatomical differences across milestone infant ages, providing a foundational resource. We showcase two applications: mapping the short-range association fibers and charting the differential myelination trajectories in infant brains.
Impact: The established foundational resource for infant brain research offers dense and age-specific multi-modal MRI templates. This resource empowers researchers to conduct precise neuroimaging analyses of infants, unlocking insights into brain structure, function, and connectivity in both health and disease.
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