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Abstract #2417

Diagnostic value of accurately MRI adenohypophyseal volume in evaluation of HPG axis activation in pre- and at-puberty children

Liu Qin1, Weiyin Vivian Liu2, and Liu Dong1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2MR Research, GE Healthcare, Beijing, China

Synopsis

Keywords: Normal Development, Diagnosis/Prediction, adenohypophyseal volume, adenohypophysis height, hypothalamic-pituitary-gonadal axis, central precocious puberty

Motivation: Evaluation of HPG axis activation among patients with PP or CPP is essential for treatment decisions.

Goal(s): To assess the potential diagnostic value of adenohypophysis volume (aPV).

Approach: A cohort of 593 children was included. Partial correlation analysis was conducted to examine the associations between aPV and aPH with LH peak and LH/FSH ratio. Multiple linear regression equations were constructed, and diagnostic performance was evaluated by ROC analysis and ICC analysis.

Results: This study obtained accurate pituitary volume and established predictive models for LH and LH/FSH. The study confirmed that pituitary volume better reflects the status of gonadal axis initiation.

Impact: aPV and aPH demonstrated potential diagnostic value in assessing HPG-axis initiation status. The multiple linear regression equations incorporating age, weight and adenohypophysis volume showed promise for predicting LH peak and LH/FSH ratio, providing insights into non-invasive methods for assessing precocity.

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