Abstract #2422

Application of ASL and MRE to explore changes in renal perfusion and stiffness in hypertensive patients with CKD

Yueyao Chen¹, Peiyin Luo¹, Wenxi Liu², Ruirui Qi¹, Qiuyi Chen¹, Junfeng Li¹, Qiumei Liang¹, Fanqi Meng¹, Haodong Qin³, Bernd Kuehn⁴, and Bingsheng Huang²

¹Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital (The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine), Shenzhen, China, ²Medical AI Lab,School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, China, ³MR Research Collaboration, Siemens Healthineers, Guangzhou, China, ⁴MR Application Predevelopment, Siemens Healthineers, Forchheim, Germany

Synopsis

Keywords: Kidney, fMRI Analysis, Arterial spin labeling, chronic kidney disease, hypertension, magnetic resonance elastography, perfusion assessment, renal stiffness

Motivation: Renal perfusion and stiffness help diagnose chronic kidney disease (CKD), yet the influence of hypertension on these factors remains unexplored.

Goal(s): To explore the correlation between renal perfusion and stiffness in patients with CKD with and without hypertension.

Approach: Stiffness and perfusion were measured using renal magnetic resonance elastography and arterial spin labeling, respectively. Data analysis included the t test, receiver operating characteristic curves, and Spearman correlation.

Results: Cortical perfusion and stiffness values were positively correlated in CKD patients without hypertension (r = 0.417, P = .038), whereas they did not correlate in those with hypertension (r = 0.279, P > .05).

Impact: The study confirms the correlation between renal stiffness and perfusion in differentiating hypertensive patients with CKD, suggesting the necessity of including the effects of perfusion status and hypertensive state when using stiffness values in CKD to ensure accurate assessment.

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