Meeting Banner
Abstract #2425

Analysis of Multi-delay Arterial Spin Labeling Reveals Inaccuracies in Kidney Blood Flow Using a Single Compartment Perfusion Model

Jiachen Wang1 and Adam Bush1
1University of Texas at Austin, Austin, TX, United States

Synopsis

Keywords: Kidney, Arterial spin labelling

Motivation: single compartment ASL models are less tested in the kidney and are likely distinct from brain kinetic models due to key physiological differences.

Goal(s): The goal of this study is to explore the accuracy of a single compartment, general ASL kinetic model in quantifying renal blood flow (RBF).

Approach: Seven subjects received brain and kidney ASL scans at four different delay times. Quantitative RBF and cerebral blood flow (CBF) maps were compared using paired t-test.

Results: RBF estimates were less stable and more dependent on delay times than CBF estimates. Cortical RBF and corticomedullary RBF ratio was lower at long delay times.

Impact: This study highlights the limitations of directly applying brain kinetic models to the kidney and calls for revised models that better accommodate kidney physiology.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords