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Abstract #2426

Free-breathing quantification of renal oxygenation with field-insensitive T2-preparation and velocity-selective EPI acquisition

Qingyu Xu1, Dengrong Jiang2, Yi Zhang1, Yi-cheng Hsu3, Hanzhang Lu4, Dan Wu1, and Zixuan Lin1
1Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 2School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3MR Collaboration, Siemens Healthineers Ltd, Shanghai, China, 4Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Kidney, Kidney

Motivation: The development of a non-contrast and robust MRI technique for renal oxygen metabolism quantification can help in both diagnosis and prognosis in kidney diseases.

Goal(s): To propose a motion-robust free-breathing method for renal oxygenation quantification.

Approach: A method using field-insensitive T2-preparation and Fourier-transform based velocity-selective EPI-readout was proposed. In-vivo experiments were conducted to exam stability and test-retest reproducibility. Caffeine challenge was performed to exam sensitivity.

Results: In-vivo experiments showed a good stability consistent with numerical simulation and a high test-retest reproducibility. The sensitivity to renal oxygenation change was shown in caffeine challenge study, where renal metabolic rate of oxygen increased after caffeine intake.

Impact: The proposed method has the potential to provide accurate and stable estimation for renal oxygenation quantification.

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