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Abstract #2427

Feasibility of an MRI Compatible Ex-vivo Model of the Human Kidney to Assess Flow and Perfusion

James Rice1,2, Gregory Simchick2, Leah Gober3, Daniel Rice3, Jennifer Philip3, Diego Hernando2,4, and Alejandro Roldan-Alzate1,2
1Mechanical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 2Radiology, University of Wisconsin - Madison, Madison, WI, United States, 3Surgery, University of Wisconsin - Madison, Madison, WI, United States, 4Medical Physics, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Keywords: Kidney, Kidney, 4D Flow MRI, IVIM

Motivation: There is a clinical need for evaluation of deceased donor kidneys prior to transplantation. Coupling ex-vivo models with quantitative MRI may enable deceased donor kidney assessment based on flow and perfusion.

Goal(s): To recreate machine perfusion conditions using an ex-vivo kidney model and assess perfusion using 4D Flow MRI and IVIM techniques.

Approach: An MRI-compatible ex-vivo kidney perfusion model was developed to visualize and quantify kidney flow using quantitative MRI techniques.

Results: The ex-vivo perfusion system replicated conditions observed under artificial kidney perfusion pre-transplantation. MRI-derived flow rate matched flow control parameters. Perfusion-related IVIM estimates demonstrated dependencies on perfusate flow rate.

Impact: MRI compatible ex-vivo models allow us to simulate in vivo flow and perfusion in a controlled and biologically consistent manner. Using 4D flow MRI and IVIM, flow and perfusion can be investigated to evaluate kidney preservation parameters and condition.

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Keywords