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Abstract #2433

Evaluation of Renal Perfusion and Oxygenation Characteristics in Patients with Sickle Cell Disease: Preliminary Findings

Durga Udayakumar1, Kabir Olaniran2, Qing Yuan3, Robert Toto2, and Ananth Madhuranthakam1,3
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Internal Medicine, Nephrology, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiology, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Kidney, Kidney

Motivation: Chronic kidney disease (CKD) is a major cause of morbidity and mortality in patients with sickle cell disease (SCD).

Goal(s): To evaluate quantitative MRI in SCD patients and compare against healthy volunteers (HV) and CKD patients without SCD.

Approach: SCD (n=6), CKD (n=7), and HV (n=6) imaged with ASL (perfusion) and BOLD (oxygenation).

Results: In SCD, (i) perfusion was statistically lower than CKD (P=0.01) but not different from HV (P=0.07); (ii) T2* (and R2*) in cortex were significantly lower (and higher) than HV and CKD (P<0.001); and (iii) T2* (and R2*) in medulla were substantially lower (and higher) compared to CKD (P<0.001).

Impact: Noninvasive, non-contrast ASL measured perfusion and BOLD measured T2* and R2* provide early functional characterization of kidneys that could facilitate longitudinal monitoring and therapeutic interventions in patients with sickle cell disease (SCD).

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Keywords