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Abstract #2454

Rapid Whole-Brain Mapping of B0, B1, and T1 for Unbiased CEST Imaging in Clinical MRI

Yupeng Wu1, Siyuan Wang2, Yang Song3, and Jianqi Li1
1Shanghai key lab of magnetic resonance, East China Normal University, Shanghai, China, 2Zhejiang A&F University, Hangzhou, China, 3MR Research Collaboration Team, Siemens Healthineers Ltd. CITY, Shanghai, China

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE, B0/B1/T1

Motivation: Clinical CEST imaging has bias issues due to hardware and relaxation factors. B1 and T1 corrections are seldom used in large cohorts because of time-consuming mapping methods.

Goal(s): To develop a fast whole-brain imaging method for B0, B1, and T1 mapping, which can promote clinically unbiased CEST imaging.

Approach: Four steady-state SPGR scans and relevant techniques were employed to create whole-brain B0, B1, and T1 maps, which were then registered to CEST images for correction.

Results: The generated maps have low relative error and difference in comparison to references. CEST images exhibit improved spatial uniformity and contrast after B1 and T1 correction.

Impact: Facilitates unbiased CEST imaging in clinical practice. Enables clinicians to detect CEST effects related to proteins/metabolites more accurately. May stimulate new clinical research on CEST-related topics.

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Keywords