Meeting Banner
Abstract #2455

A Japanese Locus Coeruleus MRI template at 7T MRI and application for assessing the link between LC structural integrity and motor function

Atsushi Yokoi1,2 and Ikuhiro Kida1,2
1National Institute of Information and Communications Technology, Suita, Japan, 2Graduate School of Frontier Biosciences, Osaka University, Suita, Japan

Synopsis

Keywords: Magnetization Transfer, biomarkers, locus coeruleus

Motivation: The current LC MRI templates are heavily based on Western brains, raising a concern about whether they are equally effective for brains of different ethnicities.

Goal(s): Our goal was to develop an LC MRI template for Eastern brains and evaluate it.

Approach: We developed an LC MRI template in Japanese populations at 7T MRI and compared it with existing templates. Using the template, we also evaluated the link between the LC structural integrity and motor-related behavior.

Results: Our template showed significantly less spatial bias than existing one when applied to Japanese brain. LC structural integrity correlated with motor learning rate.

Impact: The current results highlight the importance of using ethnically-matched brain templates to study LC in specific ethnic group. Our results also suggest a potential behavioral marker for assessing LC disfunction caused by PD or AD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords