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Abstract #2459

Testing the Efficacy of Retrospective B1+ Inhomogeneity Correction for 7T Chemical Exchange Saturation Transfer Imaging of Human Glioma

Yuxin Lan1 and Anke Henning1
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: CEST / APT / NOE, Analysis/Processing, B1 correction

Motivation: For Chemical Exchange Saturation Transfer (CEST) imaging of human glioma at 7T, the contrast corresponding to the tumor area is often masked by the effects of B1+ inhomogeneity.

Goal(s): Retrospective B1+ inhomogeneity correction using CEST data acquired using circularly polarized (CP) mode at multiple B1 levels can potentially reduce the image inhomogeneity.

Approach: Using both spline and linear interpolation methods, contrast- and Z-spectrum-based corrections are tested on 7T CEST data from glioma patients.

Results: The interpolation-based retrospective B1+ inhomogeneity correction has shown mixed effects for the CEST contrast.

Impact: Retrospective correction for B1+ inhomogeneity has limited effects in improving CEST image quality acquired using CP mode at 7T, thus presenting a demand for alternative methods to archive homogeneous CEST contrast at time of acquisition.

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