Keywords: CEST / APT / NOE, CEST & MT
Motivation: This study addresses the need for precise, region-specific assessment of glucose uptake in the kidney, aiming to enhance understanding of renal physiology and pathology through improved DGE MRI.
Goal(s): The goal of this research is to measure a full Z-spectrum at sufficient temporal resolution combined with model-based analysis techniques.
Approach: We applied a modified Bloch-McConnell equation fitting approach, using MRI data from a wildtype mouse with controlled glucose infusions, to capture regional glucose dynamics in renal tissues.
Results: The adapted model successfully quantified glucose uptake in distinct kidney regions, achieving consistent amplitude patterns over time and highlighting region-specific glucose distribution.
Impact: This work provides a refined method based on Bloch-McConnell fitting for quantifying renal DGE MRI data, enabling clearer insights into renal function and pathology. It opens new pathways for studying regional kidney metabolism and renal diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords