Meeting Banner
Abstract #2464

Motion-robust accelerated in vivo CEST MRI of perirenal fat with keyhole k-space acquisition

Zoheb Ahasan1, Mehran Shaghaghi2, Zimeng Cai3, and Kejia Cai2
1Biomedical Engineering, University Of Illinois at Chicago, Chicago, IL, United States, 2Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, 3Department of Radiology, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE, Brown Adipose Tissue, Creatine, Keyhole Reconstruction

Motivation: Quantifying creatine metabolism in perirenal fat offers insights into adipose tissue's role in energy regulation and metabolic disorders, but respiratory motion and organ displacement make reliable imaging challenging.

Goal(s): To develop a motion-robust method for accelerated CEST MRI quantification of creatine in perirenal fat.

Approach: Integrated three techniques: Savitzky-Golay filtering for spectral smoothing, Low-Rank Approximation of Z-spectra (LRAZ) for motion correction, and keyhole k-space reconstruction for faster acquisition.

Results: The method achieved 4 times reduction in scan time while maintaining measurement accuracy, with no significant differences (p>0.05) in CrCEST effects compared to conventional full k-space acquisition.

Impact: This novel integration of motion correction techniques with accelerated acquisition enables motion-robust in vivo CrCEST imaging of perirenal fat, potentially advancing our understanding of adipose tissue metabolism in obesity-related disorders while significantly reducing patient scan times.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords