Abstract #2467

Optimization of CEST saturation parameters at 1.5T for brain tumor imaging

Zhechuan Dai¹, Yifeng Zheng^2,3, Hao Chen^2,3, Yi-Cheng Hsu⁴, Kuang Liu^2,3, Haifeng Qian^2,3, and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, ²Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang, China, ³Huzhou Central Hospital, Huzhou, Zhejiang, China, ⁴MR Collaboration, Siemens Healthcare Ltd., Shanghai, China

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE

Motivation: 1.5T CEST is more challenging to recognize tumor regions compared to 3T due to reduced signal-to-noise ratio (SNR) and a coarser spectral resolution.

Goal(s): Optimize CEST saturation to maximize the tumor-cNAWM contrast.

Approach: Seven-pool Bloch-McConnell equation were utilized to fit 1.5T and 3T CEST data of health volunteers. Parameters were then fine-tuned to match cNAWM and tumor data. Fitted parameters were utilized in simulation under different saturation parameters to maximize tumor-cNAWM contrast.

Results: Ten 100ms Gaussian pulses, 95% DC and 1 µT B₁ are optimized to generate maximum tumor-cNAWM contrast at 1.5T, subject to practical acquisition time and hardware constraints.

Impact: Our optimized CEST saturation parameters maximizes tumor contrast at 1.5T, facilitating the applicability of CEST MRI with reduced SNR and a coarser spectral resolution at 1.5T.

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