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Abstract #2475

Cerebral blood volume mapping using hyperoxia and oxygenation-sensitive MRI is robust to O2-induced hypocapnia

Gabriel Hoffmann1,2, Elisa Saks1,2, Nicholas Blockley3, Claus Zimmer1,2, Christine Preibisch1,2,4, and Stephan Kaczmarz1,2,5
1School of Medicine and Health, Institute for Neuroradiology, Technical University of Munich, Munich, Germany, 2School of Medicine and Health, TUM-Neuroimaging Center, Technical University of Munich, Munich, Germany, 3School of Life Science, University of Nottingham, Nottingham, United Kingdom, 4School of Medicine and Health, Clinic of Neurology, Technical University of Munich, Munich, Germany, 5Philips GmbH Market DACH, Hamburg, Germany

Synopsis

Keywords: Oxygenation, fMRI Acquisition, Cerebral Blood Volume

Motivation: Cerebral Blood Volume (CBV) is a critical parameter for clinical diagnosis and neuroscientific applications (e.g. quantitative BOLD-fMRI), yet traditional CBV-mapping MRI is limited by contrast-agent injection. A non-invasive alternative is hyperoxia (HOX) based BOLD-fMRI.

Goal(s): This study examines HOX-induced hypocapnia (reduced CO2-levels) as a potential confounder in HOX-CBV-mapping.

Approach: We acquired dual-echo pseudo-continuous Arterial Spin Labeling (de-pCASL) data from 15 volunteers while administering 100% O2 and recording end-tidal (et) O2 and etCO2. Temporal dynamics were also evaluated within different HOX-periods.

Results: Hyperoxia moderately decreased etCO2 and CBF, while HOX-CBV remained stable across time periods, confirming reliable non-invasive CBV estimation using HOX-fMRI.

Impact: This study supports hyperoxia (HOX) BOLD-fMRI as promising for non-invasive CBV-mapping. Despite moderate HOX-induced hypocapnia, CBV remained stable. Thus HOX-CBV may enhance neuroscientific research, especially for quantitative BOLD-fMRI. Also, it may facilitate clinical imaging in patients with contrast-agent contraindications.

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