Abstract #2476

Calf muscle oxygen extraction fraction measurement using the multi contrast EPI with keyhole sequence – feasibility study.

Marzena Wylezinska-Arridge^1,2, Chiara Pizzamiglio³, Fabian Küppers ⁴, N. Jon Shah^4,5,6,7, Laura Mancini^1,2, David Thomas², Robert D.S. Pitceathly^3,8, and John S Thornton^1,2

¹Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ²Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, London, United Kingdom, ³Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁴Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, ⁵Institute of Neuroscience and Medicine 11, Forschungszentrum Jülich, Jülich, Germany, ⁶JARA_BRAIN -Translational Medicine, Aachen, Germany, ⁷Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany, ⁸NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, United Kingdom

Synopsis

Keywords: Oxygenation, Muscle, Oxygen metabolism in muscle

Motivation: Muscle Oxygen extraction fraction (OEF) may provide a potential biomarker of muscular disease.

Goal(s): The aim was to investigate application of a recently developed multi contrast EPI with keyhole sequence (GE-SE-EPIK) to quantify OEF in skeletal muscle.

Approach: Sequence was used to measure T2, T2* and OEF in healthy volunteers calf muscle at rest (to test reproducibility) and during a cuff compression (to test sensitivity to detect dynamic OEF changes).

Results: Values of T2, T2* and OEF measured at rest, correspond to those in literature. Sufficient reproducibility and sensitivity suggest suitability of GE-SE_EPIK for in vivo measurements for functional imaging of calf muscle.

Impact: This work supports the feasibility of using a recently developed multi contrast EPI with keyhole sequence to quantify T2, T2* and oxygen extraction fraction in skeletal muscle. This could prove a valuable tool for studying oxygen metabolism in muscles in health and disease.

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