Abstract #2482

Non-contrast MR imaging of blood-brain barrier permeability to water at 5T: Improved reliability compared to 3T

Shuwan Yu¹, Shuo Chen², Peiwen Sui¹, Qingyu Xu³, Ne Yang⁴, Xin Ye⁵, Xijing Zhang⁶, Jiayu Zhu⁷, Hanzhang Lu⁸, Xihai Zhao¹, and Zixuan Lin³

¹School of Biomedical Engineering, Tsinghua University, Beijing, China, ²Shanghai United Imaging Healthcare, Shanghai, China, ³Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ⁴United Imaging Research Institute of Intelligent Imaging, Beijing, China, ⁵Shanghai United Imaging Healthcare Advanced Technology Research Institute Co., Ltd., Shanghai, China, ⁶United Imaging Research, MR Research Collaboration, Shanghai, China, ⁷Central Research Institute, United Imaging Healthcare Group, Shanghai, China, ⁸The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, Perivascular adipose tissue; Carotid artery; Vulnerable plaque

Motivation: WEPCAST MRI was proposed for non-contrast assessment of BBB permeability, but is plagued by low SNR.

Goal(s): This study aimed to examine the efficacy of WEPCAST at 5T for more reliable BBB evaluation.

Approach: Labeling efficiency of ASL at 5T was estimated using phase-contrast MRI as normalization. Then, WEPCAST MRI was harmonized at 3T and 5T. The consistency of BBB permeability PS value at both fields and SNR were evaluated.

Results: ASL labeling efficiency was 0.55±0.08 at 5T. A strong correlation was found between PS measured at 3T and 5T (R²=0.806). Both spatial and temporal SNRs at 5T were significantly higher than 3T.

Impact: We proposed a WEPCAST imaging protocol at 5T that provided a superior performance in BBB assessment when compared to 3T, highlighting the potentials of 5T MRI in physiological imaging of the brain.

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