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Abstract #2520

Multiparametric MRI assessment of neuronal vascular unit destruction in rats after cerebral ischemia reperfusion injury

XiaoLi Wang1,2, XiZhen Wang1, HaiMo Zhang2, Zhen Li1, ShaoKun Hu2, XiaoZu Zhang2, YouCheng Qin2, YongJun Cheng3, and Peng Wu3
1Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China, 2School of Medical Imaging, Shandong Second Medical University, Weifang, China, 3Philips Healthcare, Shanghai, China

Synopsis

Keywords: Stroke, Stroke, Acute ischemic stroke (AIS), cerebral ischemia reperfusion injury (CIRI), neurovascular unit (NVU), blood-brain-barrier (BBB)

Motivation: Exploring an MRI assessment method that offers a noninvasive way to monitor NVU damage after IS.

Goal(s): To assess neurovascular unit (NVU) damage in cerebral ischemia reperfusion injury (CIRI) rats to provide a visual basis for clinical diagnosis and treatment of CIRI.

Approach: Establishment of CIRI rats, multiparametric MRI combined with various histological techniques.

Results: CIRI leads to NVU injury, blood-brain-barrier (BBB) disruption, and exacerbation of brain damage in rats. Multiparametric MRI combined with various histopathological techniques effectively assesses NVU injury after CIRI.

Impact: The pathological hallmarks of acute ischemic stroke (AIS) are NVU damage and BBB destruction, and its clinical treatment has shifted from single neuron protection to NVU protection, which has become a new target for studying neuronal damage and protection mechanisms.

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