Keywords: Stroke, Stroke, Acute ischemic stroke (AIS), cerebral ischemia reperfusion injury (CIRI), neurovascular unit (NVU), blood-brain-barrier (BBB)
Motivation: Exploring an MRI assessment method that offers a noninvasive way to monitor NVU damage after IS.
Goal(s): To assess neurovascular unit (NVU) damage in cerebral ischemia reperfusion injury (CIRI) rats to provide a visual basis for clinical diagnosis and treatment of CIRI.
Approach: Establishment of CIRI rats, multiparametric MRI combined with various histological techniques.
Results: CIRI leads to NVU injury, blood-brain-barrier (BBB) disruption, and exacerbation of brain damage in rats. Multiparametric MRI combined with various histopathological techniques effectively assesses NVU injury after CIRI.
Impact: The pathological hallmarks of acute ischemic stroke (AIS) are NVU damage and BBB destruction, and its clinical treatment has shifted from single neuron protection to NVU protection, which has become a new target for studying neuronal damage and protection mechanisms.
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