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Abstract #2521

Characterizing axonal damage in ischemic stroke using AxCaliber MRI in high-gradient diffusion imaging

Aneri Bhatt1,2, Liqi Shu2,3, David J. Lin2, and Susie Y. Huang1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Warren Alpert Medical School of Brown University, Providence, RI, United States

Synopsis

Keywords: Stroke, Microstructure

Motivation: Stroke is characterized histopathologically by axonal damage and loss. We propose and validate a novel marker for this damage following ischemic injury, to quantify changes at the microstructural level.

Goal(s): We aim to develop an optimized protocol for high-gradient diffusion MRI to estimate cellular damage from ischemic stroke.

Approach: We acquired diffusion MRI in patients with stroke and applied the AxCaliber methodology to estimate axon diameter and restricted volume fraction in fiber tracts of affected and contralateral hemispheres.

Results: Affected hemispheres show significantly decreased restricted volume fraction in the posterior limb of the internal capsule and the corona radiata.

Impact: AxCaliber-SMT applied to high-gradient diffusion MRI data offers a novel approach to probe axonal microstructural alterations following ischemic stroke and may aid in developing a sensitive imaging marker for evaluating rehabilitation strategies.

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Keywords