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Abstract #2523

Myelin quantity in a normal-appearing regions as a prognostic factor 3 months post ischemic stroke

Cheol-Woon Kim1, Dohyeon Kim1, Jonghun Lee1, Junbeom Lee1, Do Yeon Kim2, and Joon Yul Choi1
1Department of Biomedical Engineering, Yonsei University, Wonju, Korea, Republic of, 2Department of Neurology and Cerebrovascular Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea, Republic of

Synopsis

Keywords: Stroke, Stroke

Motivation: This study demonstrates the role of myelin integrity in post-stroke recovery, specifically in non-lesioned brain regions.

Goal(s): The goal is to investigate whether myelin-enhanced values (MEV) in non-lesioned brain areas correlate with favorable outcomes, providing insights into their predictive value for stroke recovery.

Approach: Thirty-two ischemic stroke patients underwent T1-weighted and T2-weighted FLAIR MRI. MEV in non-lesioned regions was quantified, and predictive models were built to assess associations with 3-month clinical outcomes.

Results: Higher non-lesion MEV was significantly associated with favorable outcomes, improving predictive accuracy in ensemble models by 20%.

Impact: Identifying non-lesion MEV as a predictor for stroke recovery aids in prognosis and guides personalized post-stroke management for improved patient outcomes.

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