Keywords: Stroke, Stroke, brain aging; glymphatic dysfunction; neurofluids; neurological deficits
Motivation: to understand the interplay between glymphatic system dysfunction and accelerated brain aging after ischemic stroke
Goal(s): comprehensively assess glymphatic function and its relationship with brain aging and neurological outcomes in stroke patients
Approach: Sixty stroke patients and 68 healthy controls underwent MRI and clinical evaluations to analyze glymphatic metrics and brain age differences
Results: Stroke patients showed reduced brain blood flow, accelerated aging, and glymphatic dysfunction, with significant correlations between these factors and increased neurological impairment
Impact: the study give a new perspective on stroke that Ischemic stroke impairs glymphatic system function, which may contribute to accelerated brain aging during the early period
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