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Abstract #2528

Impaired glymphatic system, accelerated brain aging, and their interconnections in ischemic stroke patients within one week

Yuanhao Li1, Houming Su1, Haorui Wan1, and Wenzhen Zhu1
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Synopsis

Keywords: Stroke, Stroke, brain aging; glymphatic dysfunction; neurofluids; neurological deficits

Motivation: to understand the interplay between glymphatic system dysfunction and accelerated brain aging after ischemic stroke

Goal(s): comprehensively assess glymphatic function and its relationship with brain aging and neurological outcomes in stroke patients

Approach: Sixty stroke patients and 68 healthy controls underwent MRI and clinical evaluations to analyze glymphatic metrics and brain age differences

Results: Stroke patients showed reduced brain blood flow, accelerated aging, and glymphatic dysfunction, with significant correlations between these factors and increased neurological impairment

Impact: the study give a new perspective on stroke that Ischemic stroke impairs glymphatic system function, which may contribute to accelerated brain aging during the early period

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Keywords