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Abstract #2563

Cerebral blood flow changes and their genetic mechanisms in Autism spectrum disorder: a combined neuroimaging and transcriptome study

Jixin Luan1 and Guolin Ma1
1Department of Radiology, China-Japan Friendship Hospital, Beijing, China

Synopsis

Keywords: Adolescents, Pediatric

Motivation: Investigating genetic mechanisms underlying cerebral blood flow (CBF) changes in Autism Spectrum Disorder (ASD) to uncover brain pathophysiology and potential therapeutic targets through integrated neuroimaging and transcriptome data.

Goal(s): To identify genes linked to CBF alterations in ASD, enhancing understanding of neuropathology and supporting targeted interventions.

Approach: Neuroimaging and transcriptome analyses of ASD and typically developing children were mapped to gene expression patterns associated with CBF, with functional insights from the Allen Human Brain Atlas.

Results: Distinct CBF patterns and gene expression changes in ASD revealed pathways in ion transport and neuronal signaling, suggesting genetic bases for CBF disruptions.

Impact: This study highlights specific genetic targets involved in ASD-related CBF abnormalities, guiding future research into therapeutic strategies. Insights into these mechanisms could support novel interventions tailored to address the unique brain perfusion profiles observed in individuals with ASD.

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