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Abstract #2567

A preliminary study of NODDI in detecting cortical microstructure injury in Children with MOGAD

Hua Cheng1, Yifan Li1, Weihua Zhang1, Changhong Ren1, Baiyan Jiang2, and Dandan Zheng2
1Beijing Children's Hospital, Capital Medical University, Beijing, China, 2Clinical & Technical Support, Philips Healthcare, Beijing, China

Synopsis

Keywords: Neuro, Pediatric, NODDI, MOGAD, GBSS, Acquired Demyelinating Disease

Motivation: Demyelinating diseases primarily focus on WM microstructures, while GM alterations, especially in pediatric patients with MOGAD, remain underexplored.

Goal(s): This study aims to investigate cortical GM microstructure damage in MOGAD patients using the NODDI model.

Approach: We applied GBSS analysis to compare NODDI metrics between 31 MOGAD patients and 29 controls, and assessed correlations with clinical scores.

Results: Our study revealed GM microstructural impairment in pediatric MOGAD patients. Increased ODI in the MOGAD group was linked to cognitive deficits, suggesting ODI as a potential biomarker for GM pathology in MOGAD.

Impact: Our study demonstrated that ODI is a potential biomarker for GM pathology in pediatric MOGAD. Future research could explore how NODDI metrics predict progression and response to treatment in demyelinating diseases.

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