Abstract #2575

Association of maternal antenatal anxiety with amygdala-prefrontal cortex functional connectivity in children from a South African cohort

Marlie Miles¹, Catherine J Wedderburn¹, Graeme Fairchild², Marilyn Lake¹, Annerine Roos¹, Katherine L Narr³, Shantanu Joshi³, Marina Lawrence¹, Nadia Hoffman¹, Nynke A Groenewold¹, Whitney Barnett⁴, Stéfan du Plessis⁵, Jonathan Ipser¹, Sarah L Halligan², Heather J Zar¹, Dan J Stein¹, and Kirsten A Donald¹

¹University of Cape Town, Cape Town, South Africa, ²University of Bath, Bath, United Kingdom, ³University of California, Los Angeles, CA, United States, ⁴Vanderbilt University, Nashville, TN, United States, ⁵Stellenbosch University, Stellenbosch, South Africa

Synopsis

Keywords: Prenatal, Psychiatric Disorders, Maternal Antenatal Anxiety, Amygdala-prefrontal cortex connectivity, Low- and middle- income countries (LMICs), Child Neurodevelopment

Motivation: Pregnant women in low- and middle-income countries (LMICs) experience high anxiety risks, with unknown effects on child brain and behaviour outcomes.

Goal(s): This study examines the impact of antenatal maternal anxiety on child amygdala-prefrontal cortex functional connectivity using fMRI in a South African birth cohort.

Approach: We compared functional connectivity outcomes between children exposed to maternal antenatal anxiety and those unexposed.

Results: Findings show that at age 2-3 years, functional connectivity between the amygdala and both the medial- and lateral- prefrontal cortex is weaker in children exposed to anxiety, particularly in boys. Additionally, amygdala-anterior cingulate connectivity is correlated with externalising behaviour.

Impact: Our findings suggest that antenatal maternal anxiety may impact child brain development. Understanding these effects could inform interventions to optimise neurodevelopment. Further research is needed to determine if these effects persist and relate to psychopathology in adolescents.

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