Keywords: Pulse Sequence Design, Acquisition Methods
Motivation: Direct myelin imaging is a promising technique for assessing myelin-related disorders. However, long scan time can introduce unwanted motion artifacts that impairs the sensitivity of myelin detection.
Goal(s): This study aims to demonstrate the efficacy of self-gated IR-UTE for improved myelin imaging.
Approach: A self-navigator was placed at the end of spokes within each segment to correct motion during IR-UTE imaging. The impact of gating was investigated using two different view ordering schemes: sequential and bit-reverse.
Results: Self-gating with bit-reverse improved myelin detection in the presence of motion. Additionally, bit-reverse ordering significantly reduced the side effects of gating compared to sequential view ordering.
Impact: The proposed technique may provide a critical tool for assessing demyelination and remyelination in various neurological disorders, including multiple sclerosis, Alzheimer’s disease, traumatic brain injury, and epilepsy, with reduced sensitivity to intra-scan motion.
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