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Abstract #2587

Self-Gated Inversion Recovery Prepared Ultrashort Echo Time Sequence for Improved Direct Myelin Imaging

Jinil Park1, Sam Sedaghat2, Youngkyoo Jung1, Eddie Fu1, Kader Oguz1, and Hyungseok Jang1
1Department of Radiology, University of California, Davis, Sacramento, CA, United States, 2Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany

Synopsis

Keywords: Pulse Sequence Design, Acquisition Methods

Motivation: Direct myelin imaging is a promising technique for assessing myelin-related disorders. However, long scan time can introduce unwanted motion artifacts that impairs the sensitivity of myelin detection.

Goal(s): This study aims to demonstrate the efficacy of self-gated IR-UTE for improved myelin imaging.

Approach: A self-navigator was placed at the end of spokes within each segment to correct motion during IR-UTE imaging. The impact of gating was investigated using two different view ordering schemes: sequential and bit-reverse.

Results: Self-gating with bit-reverse improved myelin detection in the presence of motion. Additionally, bit-reverse ordering significantly reduced the side effects of gating compared to sequential view ordering.

Impact: The proposed technique may provide a critical tool for assessing demyelination and remyelination in various neurological disorders, including multiple sclerosis, Alzheimer’s disease, traumatic brain injury, and epilepsy, with reduced sensitivity to intra-scan motion.

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Keywords