Meeting Banner
Abstract #2593

Highly Accelerated Pulmonary MRI Using RF Depolarization of 129Xe: The Sectoral Pulse Sequence

Samuel Perron1, Matthew S Fox1,2,3, and Alexei Ouriadov1,3,4
1Physics & Astronomy, The University of Western Ontario, London, ON, Canada, 2Medical Biophysics, The University of Western Ontario, London, ON, Canada, 3Lawson Research Institute, London, ON, Canada, 4School of Biomedical Engineering, The University of Western Ontario, London, ON, Canada

Synopsis

Keywords: Pulse Sequence Design, Hyperpolarized MR (Gas)

Motivation: Lung MRI using hyperpolarized 129Xe is an important but expensive diagnostic tool for various pulmonary diseases. Reducing scan times and the xenon dose required for a clinically-viable lung image would drastically lower the barrier to entry for pulmonary imaging.

Goal(s): We intend to use the RF depolarization of xenon to accelerate lung images and reduce the required amount of inhaled 129Xe.

Approach: Various sampling schemes for the Sectoral pulse sequence are developed and compared with the gradient echo sequence.

Results: The proposed method, coupled with the short-Sectoral sampling scheme, allows for aggressive undersampling with a third of a typical xenon dose.

Impact: We present a significant acceleration method which uses RF depolarization of hyperpolarized gas in lungs to reduce 129Xe dose costs. This method results in clinically-viable lung images with up to 10-fold acceleration possible with a 3-fold reduction in 129Xe dose.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords