Keywords: Pulse Sequence Design, Hyperpolarized MR (Gas)
Motivation: Lung MRI using hyperpolarized 129Xe is an important but expensive diagnostic tool for various pulmonary diseases. Reducing scan times and the xenon dose required for a clinically-viable lung image would drastically lower the barrier to entry for pulmonary imaging.
Goal(s): We intend to use the RF depolarization of xenon to accelerate lung images and reduce the required amount of inhaled 129Xe.
Approach: Various sampling schemes for the Sectoral pulse sequence are developed and compared with the gradient echo sequence.
Results: The proposed method, coupled with the short-Sectoral sampling scheme, allows for aggressive undersampling with a third of a typical xenon dose.
Impact: We present a significant acceleration method which uses RF depolarization of hyperpolarized gas in lungs to reduce 129Xe dose costs. This method results in clinically-viable lung images with up to 10-fold acceleration possible with a 3-fold reduction in 129Xe dose.
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