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Abstract #2665

Quantitative assessment of liver fibrosis by using hepatocyte uptake ratio based on T1 mapping

Ge Zhang1, Xinming Li1, Xianyue Quan1, Queenie Chan2, and Xuan Jin3
1Department of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China, guangzhou, China, 2Philips Healthcare, Hong Kong, China, Hong Kong, China, 3Department of Radiology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang,China, Yiwu, China

Synopsis

Keywords: Liver, Body

Motivation: To explore a more accurate and non-invasive method for the diagnosis of liver fibrosis.

Goal(s): To explore the potential of T1 mapping-related parameters, especially hepatocyte uptake ratio, for the diagnosis of liver fibrosis.

Approach: Investigating the correlation between T1 mapping-related parameters and the degree of liver fibrosis and evaluating the efficiency of all parameters for diagnosing liver fibrosis.

Results: Our results showed that hepatocyte uptake ratio exhibited a declining trend as the liver fibrosis progressed and outperformed serologic scores and liver-to-spleen signal intensity ratio when diagnosing liver fibrosis.

Impact: To our knowledge, this study marks the first time hepatocyte uptake ratio has been used to stage liver fibrosis, which offers a fresh perspective and paves the way for more accurate evaluation for liver fibrosis in the future.

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