Abstract #2666

Baseline predictors of adipose tissue proton density fat fraction (PDFF) reduction in participants undergoing metabolic bariatric surgery

Vitor Fernandes Martins¹, Melissa Silva¹, Danielle Batakis¹, Jake Weeks¹, Yesenia Covarrubias¹, Tanya Wolfson¹, Walter Henderson¹, David T Harris², Eduardo Grunvald³, Jeffrey Schwimmer³, Ryan Broderick³, Garth Jacobsen³, Luke Funk², Anne Lidor², Rashmi Agni², Ryan Sappenfield², Scott B Reeder², and Claude B Sirlin¹

¹Radiology, University of California San Diego, San Diego, CA, United States, ²University of Wisconsin-Madison, Madison, WI, United States, ³University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: Endocrine, Quantitative Imaging

Motivation: Visceral (VAT) and subcutaneous (SAT) adipose tissue PDFF are correlated to BMI and decrease with weight loss, however the underlying baseline factors associated with these changes have not yet been elucidated.

Goal(s): Our goal was to assess baseline predictors for VAT PDFF and SAT PDFF reduction after weight loss.

Approach: Baseline characteristics were assessed in participants and compared to changes in VAT and SAT PDFF 12 months after undergoing metabolic bariatric surgery.

Results: Participants with healthier metabolic profiles at baseline had more pronounced reductions in VAT and SAT PDFF 12 months after metabolic bariatric surgery.

Impact: Adipose tissue PDFF, with further research and validation, could aid as a novel metric in monitoring metabolic health in patients with obesity and during weight loss.

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