Abstract #2670

Hepatic PDFF quantification using phase-cycled bSSFP: First-in-patient study

Berk Can Acikgoz^1,2,3, Adèle L.C. Mackowiak⁴, Giulia M.C. Bongiolatti-Rossi⁴, Tom Hilbert^4,5,6, Jean-Baptiste Ledoux^4,7, Naik Vietti-Violi⁴, and Jessica A.M. Bastiaansen^1,2

¹Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, ²Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, ³Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland, ⁴Department of Radiodiagnosis and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ⁶LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁷Center for Biomedical Imaging (CIBM), Lausanne, Switzerland

Synopsis

Keywords: Liver, Liver, phase-cycled bSSFP, PDFF, patients, MASLD, steatosis

Motivation: Phase-cycled bSSFP-based fat fraction mapping has yet to be evaluated in a clinical setting involving patients.

Goal(s): To evaluate the feasibility of phase-cycled bSSFP-based fat fraction mapping in liver disease patients, assessing its capabilities and potential in clinical practice.

Approach: 2D golden angle radial phase-cycled bSSFP data were prospectively acquired in liver patients during a single breath hold. Obtained fat fraction maps were compared with Dixon-based clinical standard maps.

Results: Bland-Altman analyses with limits of agreement (LOA) of -2.5%±1.96×2.8%, and linear regression fitted lines y=1.18x+2.5 with R²=0.72, demonstrated a good agreement between phase-cycled bSSFP-based fat fraction and reference maps.

Impact: Fat fraction mapping with phase-cycled bSSFP is feasible in patients, presenting a non-invasive alternative to biopsy and MRS. Its high SNR and robustness against T1 bias might make it a powerful alternative to existing methods in liver steatosis assessment.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.