Abstract #2671

Metabolic dysfunction-associated steatohepatitis (MASH) dampens liver fat reduction in participants after metabolic bariatric surgery

Vitor Fernandes Martins¹, Danielle Batakis¹, Yesenia Covarrubias¹, Jake Weeks¹, Tanya Wolfson¹, Walter Henderson¹, David T Harris², Eduardo Grunvald¹, Jeffrey Schwimmer¹, Rya Broderick¹, Garth Jacobsen¹, Luke Funk², Anne Lidor², Rashmi Agni², Ryan Sappenfield², Scott B Reeder², and Claude B Sirlin¹

¹UC San Diego, San Diego, CA, United States, ²University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Liver, Quantitative Imaging

Motivation: Patients with MASH have increased inflammation and insulin resistance, however whether this translates to dampened liver fat reduction after weight loss is not known.

Goal(s): Our goal was to assess if patients with MASH have altered liver fat reduction after weight loss.

Approach: Baseline MASH status was determined in participants with obesity via biopsy during metabolic bariatric surgery. Liver PDFF was assessed by MRI pre-op and 12 months post-op and the changes were compared between groups.

Results: Participants with MASH had dampened reduction of liver PDFF after metabolic bariatric surgery when controlling for baseline PDFF.

Impact: For patients with obesity and MASH, adjuvant treatment may be needed to achieve the same total goal reduction in liver fat as patients without MASH.

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