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Abstract #2683

Tumour mechanics and vascular fractality quantification via MR-Elastography to gauge therapy response in liver metastasis

Asma Boumaza1, Gabrielle Mangin1, Jake Penney1, Giacomo Annio1, Samira Laouirem1, Miguel Albuquerque2, Sverre Holm3, Knut Sølna 4, Valerie Vilgrain2, Valerie Paradis2, and Ralph Sinkus5
1INSERM, PARIS, France, 2Assistance publique - Hôpitaux de Paris, PARIS, France, 3Department of Physics, University of Oslo, oslo, Norway, 4Department of Mathematics, University of California at Irvine, Irvine, CA, United States, 5School of Biomedical Engineering and Imaging Sciences, King’s College London, PARIS, France

Synopsis

Keywords: Liver, Elastography, Liver, tumor, biomechanics, Vessels

Motivation: Combination therapies using cytotoxic and anti-angiogenic drugs for hepatic metastases from colorectal cancer are currently presenting radiological challenges for monitoring treatment efficacy

Goal(s): Can vascular architecture quantified through its fractality and measured non-invasively via multi-frequency MRE be used to gauge response to novel combination therapies acting on cells and vessels simultaneously

Approach: The study used multifrequency MRE to measure the Hurst index, quantifying vascular fractality in murine models treated with different therapies.

Results: The combination of BEVACIZUMAB and FOLFOX normalized tumor vascular organization, significantly impacting vascular fractality as compared to single drug treatments. Invivo and histological vessel fractality match.

Impact: This approach offers a non-invasive biomarker for evaluating therapies, advancing personalized treatments for liver metastases

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