Keywords: Digestive, CEST / APT / NOE
Motivation: Accurate assessment of pathological complete response (pCR) after neoadjuvant therapy may help to preserve patient organs and improve quality of life.
Goal(s): This study investigated the feasibility of amide proton transfer-weighted (APTw) MR imaging in the assessment of pCR in patients with rectal cancer (RC).
Approach: Pre-treatment and post-treatment APTw MRI were analyzed, measuring APTw SI of lesion to evaluate pCR predictive potential via ROC curves.
Results: We found that rectal cancer lesions in the pCR group had a lower APTw signal intensity (SI) and a greater reduction in APTw SI after treatment compared with before treatment than those in the non-pCR group.
Impact: APTw MRI may help identify patients with a good response.
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