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Abstract #2684

Amide Proton Transfer-weighted MRI in predicting pathological complete response of rectal adenocarcinoma

Peiyi Xie1, Qitong Huang1, Long Yang1, Kexin Niu1, Deicai Ma1, and Xiaochun Meng1
1The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Synopsis

Keywords: Digestive, CEST / APT / NOE

Motivation: Accurate assessment of pathological complete response (pCR) after neoadjuvant therapy may help to preserve patient organs and improve quality of life.

Goal(s): This study investigated the feasibility of amide proton transfer-weighted (APTw) MR imaging in the assessment of pCR in patients with rectal cancer (RC).

Approach: Pre-treatment and post-treatment APTw MRI were analyzed, measuring APTw SI of lesion to evaluate pCR predictive potential via ROC curves.

Results: We found that rectal cancer lesions in the pCR group had a lower APTw signal intensity (SI) and a greater reduction in APTw SI after treatment compared with before treatment than those in the non-pCR group.

Impact: APTw MRI may help identify patients with a good response.

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Keywords